The Prevalence of Extended-Spectrum β-Lactamase Producing Enterobacteriaceae Isolated from Hospitalized Patients

Najibpour, Nasim; Hasanvand, Amin; Birjandi, Mehdi; Kharazmkia, Ali

doi:10.22087/ijac.2025.506358.1049

The Prevalence of Extended-Spectrum β-Lactamase Producing Enterobacteriaceae Isolated from Hospitalized Patients

Document Type : Research

Authors

Nasim Najibpour ¹

Amin Hasanvand ²

Mehdi Birjandi ³

Ali Kharazmkia ⁴

¹ Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran

² Department of Physiology and Pharmacology, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran

³ Assistant professor of Biostatistics, School of Health and Nutrition, Lorestan University of Medical Sciences, Khorramabad, Iran.

⁴ Department of Clinical Pharmacy, Faculty of Pharmacy, Lorestan University of Medical Sciences, Khorramabad, Iran.

10.22087/ijac.2025.506358.1049

Abstract

Broad-spectrum beta-lactamase-producing Enterobacteriaceae cause significant health issues. Owing to the increasing prevalence of antibiotic resistance, including beta-lactamase-resistant species, determining their prevalence in hospitals is particularly important. This study aimed to evaluate the frequency of extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae in clinical specimens obtained from patients admitted to Shahid Rahimi Hospital in Khorramabad. Clinical samples were obtained from hospitalized patients for 4 months, collected by census, and identified using standard biochemical methods. Antibiotic resistance testing was performed using the Kirby-Bauer method, and the ESBLs phenotype was confirmed using the combination disk test. In this study, 215 Enterobacteriaceae isolates were extracted, of which 149 were ESBL generators. The highest frequency of ESBLs among the identified bacteria was Escherichia coli (51.2%). The highest frequency of ESBL-producing isolates was in the > 65 years age group (32.6%), in urinary specimens (61.4%), and in emergency wards (24.1%). In conclusion, the high prevalence of ESBL-producing bacteria in tract infections (61.4%) shows the importance of routine testing in medical centers and the need for physicians to pay more attention to this issue.

Keywords

Enterobacteriaceae

Antibiotic Resistance

Extended Spectrum Betalactamases

Isolated

Hospitalized Patients

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