Relationship Between Common Polymorphisms of NRAMP1 Gene and Pulmonary Tuberculosis in Lor Population of Iran

Amiri, Ali; Ansari-moghaddam, Bijan; Sabooteh, Toomaj; Rostami, Sanaz; Shahsavar, Farhad

doi:10.22087/ijac.2022.460979.1011

Relationship Between Common Polymorphisms of NRAMP1 Gene and Pulmonary Tuberculosis in Lor Population of Iran

Document Type : Research

Authors

Ali Amiri ¹

Bijan Ansari-moghaddam ²

Toomaj Sabooteh ³

Sanaz Rostami ⁴

Farhad Shahsavar ⁵

¹ Hepatitis Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran

² Department of Immunology, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran

³ Hepatitis Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.

⁴ Student Research Committee, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.

⁵ Department of Immunology, Lorestant University of Medical Sciences, Khorramabad, Iran

10.22087/ijac.2022.460979.1011

Abstract

This study aimed to investigate the relationship between the common polymorphisms of the NRAMP1 gene and the genetic susceptibility to pulmonary tuberculosis in the Lur Population of Lorestan province of Iran. In this case-control study, 100 patients with pulmonary tuberculosis were studied as a case group, and 100 healthy controls were studied as controls; and three common polymorphisms of the NRAMP1 gene (3'UTR, INT4, and D543N) were genotyped using PCR-RFLP. The GG genotype of D543N polymorphism (OR=2.042, 95%CI=1.024-4.071) and G allele of D543N polymorphism (OR=2.043, 95%CI=1.140-3.663) were significantly associated with increased susceptibility to pulmonary tuberculosis. On the other hand, the frequency of allele A of D543N polymorphism was significantly lower in patients with pulmonary tuberculosis (OR=0.489, 95%CI=0.273-0.878). The GG genotype and G allele of D543N polymorphism significantly increase the genetic susceptibility to pulmonary tuberculosis in the Lur Population of Lorestan province. Also, allele A of D543N polymorphism significantly affects resistance to pulmonary tuberculosis in this population.

Keywords

NRAMP1

Pulmonary Tuberculosis

LUR Population

Lorestan Province

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