Antioxidant Activity of Capsaicin on LS-180 Cell Line

Baharvand, Parastoo; Hormozi, Maryam

doi:10.22087/ijac.2022.470227.1017

Antioxidant Activity of Capsaicin on LS-180 Cell Line

Document Type : Research

Authors

Parastoo Baharvand ¹

Maryam Hormozi ²

¹ Department of Social Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran

² Razi Herbal Medicines Research Center, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran

10.22087/ijac.2022.470227.1017

Abstract

Cancer is one of the main causes of premature death in the world, and oxidative stress plays an important role in the pathogenesis of this disease. Since there is much evidence about the anticancer effect of antioxidants, this study aims to investigate the effect of capsaicin on the activity of the antioxidant enzymes superoxide dismutase, catalase, and glutathione peroxidase in the LS-180 human colorectal cancer cell line.In this study, the human colorectal cancer cell line (LS-180) was treated with different concentrations of capsaicin for 24 hours, and then the activities of the antioxidant enzymes of superoxide dismutase, catalase, and glutathione peroxidase were determined by calorimetric methods. Analysis of the results showed that the activities of superoxide dismutase, catalase, and glutathione peroxidase enzymes increased in capsaicin-treated groups compared to the control group in the LS-180 cell line (p<0.05). Capsaicin inhibits cell proliferation by increasing the activity of antioxidant enzymes.

Keywords

Capsaicin

Antioxidant activity

LS-180 cell line

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